职称：副教授
学历:博士
电子邮件：[email protected]
教育工作经历
2024.10-至今在线体育投注平台
；
2019.8-2024.7 武汉大学医学研究院，博士后；
2011.9-2019.6 武汉大学生命科学体育投注平台
，博士；
2011.9-2013.6武汉大学生命科学体育投注平台
，硕士；
2007.9-2011.6 河南大学生命科学体育投注平台
，学士。
研究方向
1.自噬与肿瘤的发生发展
2.RNA修饰与肿瘤的发生发展
主持和参加的科研项目
(1)国家自然科学基金委员会,青年科学基金项目, 32100570,脯氨酸羟化酶EglN1转位到线粒体介导乳腺癌细胞适应缺氧应激的机制研究, 2022-01-01至2024-12-31, 30万元,在研,主持
(2)中国博士后科学基金会,中国博士后科学基金第67批面上资助二等, 2020M672408,线粒体能量代谢在乳腺癌内分泌治疗耐药产生过程中的作用机制研究, 2020-07至2022-06, 8万元,结题,主持
(3)国家自然科学基金委员会,面上项目, 31671393,线粒体外膜蛋白Sam50在线粒体动力学及线粒体自噬调控中的作用及分子机制研究, 2017-01-01至2020-12-31, 62万元,结题,参与
发表学术论文
1.Chaojun Yan, Jingjing Xiong, Zirui Zhou, Qifang Li, Chuan Gao, Mengyao Zhang, Liya Yu, Jinpeng Li, Ming-Ming Hu, Chen-Song Zhang, Cheguo Cai, Haojian Zhang and Jing Zhang. A cleaved METTL3 potentiates the METTL3-WTAP interaction and breast cancer progression.eLife. 2023, 87283:1-25.
2.Chaojun Yan, Ronghui Gao, Kai Hong, Meng Cheng, Xiaojing Liu, Qing Zhang, Jing Zhang. FDXR Drives Primary and Endocrine Resistant Tumor Cell Growth in ER+ Breast Cancer via CPT1A-Mediated Fatty Acid Oxidation.Frontiers in Oncology,2023 May 3;13:1105117.
3.Chaojun Yan, Longlong Gong, Chen Li, Meng Xu, Hussein Abou-Hamdan, Mingliang Tang, Laurent Désaubry, and Zhiyin Song.PHB2 (prohibitin 2) promotes PINK1-PRKN/Parkin-dependent mitophagy by the PARL-PGAM5-PINK1 axis.Autophagy, 2020 Mar;16(3):419-434.
4.Chaojun Yan, Xiaoying Duanmu, Ling Zeng, Bing Liu and Zhiyin Song. Mitochondrial DNA: Distribution, Mutations, and Elimination.Cells. 2019 Apr 25;8(4). pii: E379.
5.Jingjing Xiong,Chaojun Yan, Qing Zhang, Jing Zhang. α-Ketoglutarate-dependent Enzymes in Breast Cancer and Therapeutic Implications.Endocrinology. 2023 Apr 17;164(6):bqad080.
6.Jingjing Xiong, Zirui Zhou, Yulong Jiang, Qifang Li, Zuhan Geng, Jiahao Guo,Chaojun Yan, and Jing Zhang.Hypoxic stabilization of RIPOR3 mRNA via METTL3-mediated m6A methylation drives breast cancer progression and metastasis.Oncogene.2024 Nov;43(47):3426-3441.（共同通讯作者）
7. Jiang W, Zhang M, Gao C,Yan C, Gao R, He Z, Wei X, Xiong J, Ruan Z, Yang Q, Li J, Li Q, Zhong Z, Zhang M, Yuan Q, Hu H, Wang S, Hu MM, Cai C, Wu GS, Jiang C, Zhang YL, Zhang CS, Zhang J*. A mitochondrial EglN1-AMPKα axis drives breast cancer progression by enhancing metabolic adaptation to hypoxic stress.EMBO J. 2023 Oct 16;42(20):e113743.
8. Li Chen, Jun Dong, Siyang Liao, Siyou Wang, Zhida Wu, Meiling Zuo, Bing Liu,Chaojun Yan, Yong Chen, He He, Qingtao Meng, Zhiyin Song. Loss of Sam50 in hepatocytes induces cardiolipin-dependent mitochondrial membrane remodeling to trigger mtDNA release and liver injury.Hepatology, 2022 Nov;76(5):1389-1408.
9．Zhida Wu; Meiling Zuo; Ling Zeng; Kaisa Cui; Bing Liu;Chaojun Yan; Li Chen; Jun Dong; Fugen Shangguan; Wanglai Hu; He He; Bin Lu; Zhiyin Song; OMA1 reprograms metabolism under hypoxia to promote colorectal cancer development,EMBO Reports,2021, 22(1)
10. Tang J, Zhang K, Dong J,Yan C,Hu C, Ji H, Chen L, Chen S, Zhao H, Song Z. Sam50-Mic19-Mic60 axis determines mitochondrial cristae architecture by mediating mitochondrial outer and inner membrane contact.Cell Death Differ. 2019 May 16.
11. Fenglei Jian, Dan Chen, Li Chen,Chaojun Yan, Bin Lu, Yushan Zhu, Shi Chen, Anbing Shi, David C. Chan,and Zhiyin Song.Sam50 Regulates PINK1-Parkin-Mediated Mitophagy by Controlling PINK1 Stability.Cell Reports.2018 Jun 5;23(10):2989-3005.
12.Yue W, Chen ZH, Liu HY,Yan C, Chen M, Feng D, Yan C, Wu H, Du L, Wang YY, Liu JH, Huang XH, Xia LX, Liu L., Wang XH., Jin HJ, Wang J, Song ZY, Hao XJ, Chen Q.A small natural molecule promotes mitochondrial fusion through inhibition of the deubiquitinase USP30.Cell Research. 2014 Apr;24(4):482-96.
