职 称：讲师
学 历：博士
E-mail:[email protected]
研究方向：结构生物学、表观遗传学、自身免疫疾病调控蛋白的结构与功能研究
基本情况：
教育工作经历：
2013.09~2017.06，华中师范大学，应用化学、生物技术双学历，理学学士
2017.09~2020.06，华中师范大学，生物化学与分子生物学，理学硕士
2020.09~2024.06，华中师范大学，生物学，理学博士
2024.10~至今，在线体育投注平台，体育投注平台
，讲师
以第一作者或者共同作者身份在Journal of biological chemistry、Journal of molecular biology、Methods等国际期刊发表多篇研究论文，并参与国家自然科学基金研究项目。
研究课题：
国家自然科学基金委员会,面上项目, 32170906,致病性IgG-RF N-糖修饰异常诱导RA发病机制研究, 2022-01-01至2025-12-31, 58万元,在研,参与。
研究成果：
第一作者：
1. Sizhuo Chen, Ming Lei, Ke Liu, Jinrong Min. Structural basis for specific DNA sequence recognition by the transcription factor NFIL3[J]. J Biol Chem, 2024.300(3):105776.
2. Sizhuo Chen#, Mengqi Zhou#, Aiping Dong, Peter Loppnau, Min Wang, Jinrong Min, Ke Liu. Structural basis of the TAM domain of BAZ2A in binding to DNA or RNA independent of methylation status[J]. J Biol Chem, 2021. 297(6):101351.
3. Sizhuo Chen, Weilian Zhang, Jinrong Min, Ke Liu. Lesson from a Fab-enabled co-crystallization study of TDRD2 and PIWIL1[J]. Methods, 2020. 175:72-78.
4. Zhibin Wu#,Sizhuo Chen#（共同一作）, Mengqi Zhuo#, Lingbo Jia, Zhenhua Li, Xiyou Zhang, Jinrong Min, Ke Liu. Family-wide Characterization of Methylated DNA Binding Ability of Arabidopsis MBDs[J]. J Mol Biol, 2022. 434(2):167404.
参与作者：
1. Jin Zhang,Sizhuo Chen, Ke Liu. Structural insights into piRNA biogenesis[J]. Biochim Biophys Acta Gene Regul Mech, 2022. 1865(2):194799.
2. Yingying Feng,Sizhuo Chen, Mengqi Zhou, Jin Zhang, Jinrong Min, Ke Liu. Crystal structure of the BAZ2B TAM domain[J]. Heliyon, 2022. 8(7):e09873.
3. Bing Gan,Sizhuo Chen, Huan Liu, Jinrong Min, Ke Liu. Structure and function of eTudor domain containing TDRD proteins[J]. Crit Rev Biochem Mol Biol, 2019, 54, 119-132.
4. Ming Lei, Wolfram Tempel,Sizhuo Chen, Ke Liu, Jinrong Min. Plasticity at the DNA recognition site of the MeCP2 mCG-binding domain[J]. Biochim Biophys Acta Gene Regul Mech,2019, 1862, 194409.
5. Yiwen Yang#, Ke Liu#, Da Huang, Chen Yu,Sizhuo Chen, Min Chen, Baosheng Qiu. Functional specialization of expanded orange carotenoid protein paralogs in subaerial Nostoc species[J]. Plant Physiol, 2023, 192, 2640-2655.
6. Chun-Chi Chen#, Xuejing Yu#, Chih-Jung Kuo#, Jian Min,Sizhuo Chen, Lixin Ma, Ke Liu, Rey-Ting Guo. Overview of antiviral drug candidates targeting coronaviral 3C-like main proteases[J]. FEBS J, 2021.288(17):5089-5121.
